合成生物学平台

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丁伟

  • 教育背景

  • 工作经历

  • 研究方向

  • 代表性论文专著

  • 2006-2010:兰州大学生命科学院和中科院上海有机化学研究所联合培养,博士

  • 2001-2005:兰州大学生命科学院,本科

  • 2019-至今:上海交通大学生命科学技术学院,长聘教轨副教授、博导

  • 2013-2018:兰州大学生命科学院,副教授、硕导

  • 2010-2012:德国Saarland University,药物生物技术系,博士后

  • 重要生物活性天然产物的生物合成机制和合成生物学研究

  • 极端环境微生物中活性小分子和高效酶的发现

  • 酶催化机制的多样性和定向进化研究

  • 重要临床药物中间体的生物催化和微生物工业菌种的代谢工程

  • Wei Ding, Xijian Ji, Yuting Zhong, Kuang Xu, Qi Zhang*. Adenosylation reactions catalyzed by the radical S-adenosylmethionine superfamily enzymes. Curr Opin Chem Biol. 2020 Apr;55:86-95.

  • Tianlv Mo, Dhanaraju Mandalapu, Hong Yuan, Wei Ding* and Qi Zhang*.Convergent evolution of the Cys decarboxylases involved in aminovinyl-cysteine (AviCys) biosynthesis. FEBS Letters. 2019, 593(6):573-580.

  • Wei Ding, Wenjuan Ji, Yujie Wu,  Runze Wu, Wan-Qiu Liu, Tianlu Mo, Junfeng Zhao, Xiaoyan Ma, Ping Xu, Boping Tang*, Yi Yu* and Qi Zhang*. Biosynthesis of the Nosiheptide Indole Side Ring Centers on a Cryptic Carrier Protein NosJ. Nature Communications. 2017, 8(1):437.

  • Wei Ding, Yongzhen Li, Junfeng Zhao, Xinjian Ji, Tianlu Mo, Haocheng Qianzhu, Zixin Deng, Yi Yu, and Qi Zhang*. Catalytic Mechanism of the Class C radical S-Adenosylmethionine Methyltransferase. Angew. Chem. Int. Ed. 2017, 56, 3857 -3861.

  • Xinjian Ji, Yongzhen Li, Liqi Xie, Haojie Lu, Wei Ding*, and Qi Zhang* Expanding radical SAM chemistry by using radical addition reactions and SAM analogues. Angew. Chem. Int. Ed. 2016, 55, 11845-8

  • Wei Ding, Wan-Qiu Liu, Youli Jia, Yongzhen Li, Wilfred A van der Donk*, and Qi Zhang* Biosynthetic investigation of phomopsins revealed a widespread pathway for ribosomal natural products in Ascomycetes..Proc. Natl. Acad. Sci. 2016, 113, 3521-3526