课题组长
研究员
电子邮箱:chunding@sjtu.edu.cn
个人网页/课题组主页: https://pharm.sjtu.edu.cn/szdy/3384.html
教育背景
工作经历
研究方向
荣誉奖励/承担项目
代表性论文和著作
2005-2010 中国药科大学 博士(药物化学专业)
2001-2005 中国药科大学 本科(药学专业)
2020-至今 上海交通大学药学院 研究员
2019-2020 中科院上海药物研究所 研究员
2014-2019 中科院上海药物研究所 副研究员
2013-2014 中科院上海药物研究所 助理研究员
2010-2013 美国德州大学医学分部 博士后
抗肿瘤免疫小分子药物开发;药物靶标鉴定与验证;分子影像探针开发
2019 赛诺菲-中科院上海生科院优秀青年人才奖
2019 中国精准医疗大会-青年学者创新成果展示第一名
*共同通讯作者,#共同第一作者
Zhu Q#, Sun F#, Li T, Zhou M, Ye J, Ji A, Wang H*, Ding C*, Chen H, Xu Z*, Yu H*. Engineering oxaliplatin prodrug nanoparticles for second near Infrared fluorescence imaging-guided immunotherapy of colorectal cancer. Small 2021, 17(13):e2007882.
Tan J#, Wu B#, Chen T, Fan C, Zhao J, Xiong C, Feng C, Xiao R, Ding C*, Tang W*, Zhang A*. Synthesis and Pharmacological Evaluation of Tetrahydro-γ-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP-AMP Synthase. J. Med. Chem. 2021, 64(11):7667-7690.
Ding C, Song Z, Shen A, Chen T, Zhang A*, Small molecules targeting the innate immune cGAS‒STING‒TBK1 singling pathway. Acta Pharm. Sin. B, 2020, 10(12):2272-2298.
Xiao R#, Ding C#, Zhu H, Liu X, Gao J, Liu Q, Lu D, Zhang N*, Zhang A*, Zhou H*. Suppression of asparagine synthetase enhances the antitumor potency of ART and artemalogue SOMCL-14-221 in non-small cell lung cancer. Cancer Lett. 2020, 475:22-33.
Dang Y, Wang F, Li L, Lai Y, Xu Z*, Xiong Z, Zhang A, Tian Y, Ding C*, Zhang W*. An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice. Chem. Commun. 2020, 56(5):707-710.
Ding C*,#, Wang F#, Dang Y#, Xu Z*, Li L, Lai Y, Yu H, Luo Y, Huang R, Zhang A, Zhang W*. Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity. Anal. Chem. 2019, 91(24):15577-15584.
Ding C#, Chen H#, Liang B, Jiao M, Liang G*, Zhang A*. Biomimetic synthesis of the natural product salviadione and its hybrids: discovery of tissue-specific anti-inflammatory agents for acute lung injury. Chem. Sci. 2019, 10, 4667-4672.
Ding C#, Tian Q#, Li J, Jiao M, Song S, Wang Y*, Miao Z-H*, Zhang A*. Structural Modification of Natural Product Tanshinone I Leading to Discovery of Novel Nitrogen-Enriched Derivatives with Enhanced Anticancer Profile and Improved Drug-Like Properties. J. Med. Chem. 2018, 61(3), 760–776.
Wang F, Yu S, Xu Z*, Li L, Dang Y, Xu X, Luo Y, Cheng Z, Yu H, Zhang W, Zhang A, Ding C*. Acid-Promoted D-A-D Type Far-Red Fluorescent Probe with High Photostability for Lysosomal Nitric Oxide Imaging. Anal. Chem. 2018, 90(13):7953-7962.
Li R,# Ding C,# Zhang J,# Xie M, Park D, Ding Y, Chen G, Zhang G, Gilbert-Ross M, Zhou W, Marcus A I, Sun S Y, Chen Z G, Sica G L, Ramalingam S S, Magis A T, Fu H, Khuri F R, Curran W J, Owonikoko T K, Shin D M, Zhou J*, Deng X* Modulation of Bax and mTOR for Cancer Therapeutics. Cancer Res. 2017, 77, 3001-3012.