人工智能生物医药中心

4331

丁春勇

  • 教育背景

  • 工作经历

  • 研究方向

  • 荣誉奖励/承担项目

  • 代表性论文和著作

  • 2005-2010   中国药科大学  博士(药物化学专业)

  • 2001-2005   中国药科大学  本科(药学专业)

  • 2020-至今  上海交通大学药学院  研究员

  • 2019-2020  中科院上海药物研究所 研究员

  • 2014-2019  中科院上海药物研究所 副研究员

  • 2013-2014  中科院上海药物研究所 助理研究员

  • 2010-2013  美国德州大学医学分部 博士后

  • 抗肿瘤免疫小分子药物开发;药物靶标鉴定与验证;分子影像探针开发

  • 2019 赛诺菲-中科院上海生科院优秀青年人才奖

  • 2019 中国精准医疗大会-青年学者创新成果展示第一名

  • 2014 上海市浦江人才计划

    *共同通讯作者,#共同第一作者

  • Zhu Q#, Sun F#, Li T, Zhou M, Ye J, Ji A, Wang H*, Ding C*, Chen H, Xu Z*, Yu H*. Engineering oxaliplatin prodrug nanoparticles for second near Infrared fluorescence imaging-guided immunotherapy of colorectal cancer. Small 2021, 17(13):e2007882.

  • Tan J#, Wu B#, Chen T, Fan C, Zhao J, Xiong C, Feng C, Xiao R, Ding C*, Tang W*, Zhang A*. Synthesis and Pharmacological Evaluation of Tetrahydro-γ-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP-AMP Synthase. J. Med. Chem. 2021, 64(11):7667-7690.

  • Ding C, Song Z, Shen A, Chen T, Zhang A*, Small molecules targeting the innate immune cGAS‒STING‒TBK1 singling pathway. Acta Pharm. Sin. B, 2020, 10(12):2272-2298.

  • Xiao R#, Ding C#, Zhu H, Liu X, Gao J, Liu Q, Lu D, Zhang N*, Zhang A*, Zhou H*. Suppression of asparagine synthetase enhances the antitumor potency of ART and artemalogue SOMCL-14-221 in non-small cell lung cancer. Cancer Lett. 2020, 475:22-33.

  • Dang Y, Wang F, Li L, Lai Y, Xu Z*, Xiong Z, Zhang A, Tian Y, Ding C*, Zhang W*. An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice. Chem. Commun. 2020, 56(5):707-710.

  • Ding C*,#, Wang F#, Dang Y#, Xu Z*, Li L, Lai Y, Yu H, Luo Y, Huang R, Zhang A, Zhang W*. Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity. Anal. Chem. 2019, 91(24):15577-15584.

  • Ding C#, Chen H#, Liang B, Jiao M, Liang G*, Zhang A*. Biomimetic synthesis of the natural product salviadione and its hybrids: discovery of tissue-specific anti-inflammatory agents for acute lung injury. Chem. Sci. 2019, 10, 4667-4672.

  • Ding C#, Tian Q#, Li J, Jiao M, Song S, Wang Y*, Miao Z-H*, Zhang A*. Structural Modification of Natural Product Tanshinone I Leading to Discovery of Novel Nitrogen-Enriched Derivatives with Enhanced Anticancer Profile and Improved Drug-Like Properties. J. Med. Chem. 2018, 61(3), 760–776.

  • Wang F, Yu S, Xu Z*, Li L, Dang Y, Xu X, Luo Y, Cheng Z, Yu H, Zhang W, Zhang A, Ding C*. Acid-Promoted D-A-D Type Far-Red Fluorescent Probe with High Photostability for Lysosomal Nitric Oxide Imaging. Anal. Chem. 2018, 90(13):7953-7962.

  • Li R,# Ding C,# Zhang J,# Xie M, Park D, Ding Y, Chen G, Zhang G, Gilbert-Ross M, Zhou W, Marcus A I, Sun S Y, Chen Z G, Sica G L, Ramalingam S S, Magis A T, Fu H, Khuri F R, Curran W J, Owonikoko T K, Shin D M, Zhou J*, Deng X* Modulation of Bax and mTOR for Cancer Therapeutics. Cancer Res. 2017, 77, 3001-3012.