合成生物学平台

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唐满成

  • 教育背景

  • 工作经历

  • 研究方向

  • 承担项目及荣誉奖励

  • 代表性论文专著

  • 2004-2010  中国科学院上海有机化学研究所  博士

  • 1999-2003  武汉大学  学士

  • 2019-至今   上海交通大学生命科学技术学院  长聘教轨副教授

  • 2014-2018   加州大学洛杉矶分校  博士后

  • 2013-2014  中国科学院上海有机化学研究所  副研究员

  • 2010-2013  中国科学院上海有机化学研究所  助理研究员

  • 活性天然产物的发掘;天然产物生物合成与创制;高附加值小分子化学品的微生物创制

承担项目:

  • 国家自然科学基金/面上项目,22177071,01/2022-12/2025,主持(在研)

  • 国家重点研发计划“微生物药物工业底盘构建与适配性优化”,2021YFC2100600,07/2021-06/2024,子课题负责人(在研)

  • 国家重点研发计划“微生物天然产物的智能创制与改良”,2018YFA0901900,07/2019-06/2024,子课题负责人(在研)

  • 国家自然科学基金/面上项目,31971345,01/2020-12/2023,主持(在研)

荣誉奖励:

  • 2020 上海市海外高层次人才

  • Liu L., Tang M.-C.*, Tang Y.* “Fungal Highly Reducing Polyketide Synthases Biosynthesize Salicylaldehydes that are Precursors to Epoxycyclohexenol Natural Products.” J. Am. Chem. Soc. 2019, 141, 19538-19541.

  • Tang M.-C.#, Fischer C. R.#, Chari J. V., Tan D., Suresh S., Chu A., Miranda M., Smith J., Zhang Z., Garg N., St Onge R. P.*, Tang Y.* “Thioesterase-catalyzed aminoacylation and thiolation of polyketides in fungi.” J. Am. Chem. Soc. 2019, 141, 8198-8206.

  • Tan D. #, Jamieson C. S. #, Ohashi M., Tang M.-C.*, Houk K. N.*, Tang Y.* “Genome-mined Diels-Alderase catalyzes the formation of the cis-octahydrodecalins of varicidin A and B.” J. Am. Chem. Soc. 2019, 141, 769-773.

  • Harvey C. J. B.#,Tang M.#, Schlecht U., Horecka J., Fischer C. R., Lin H.-C., Li J., Naughton B., Cherry J., Miranda M., Li Y. F., Chu A. M., Hennessy J. R., Vandova G. A., Inglis D., Aiyar R., Steinmetz L. M., Davis R. W., Medema M. H., Sattely E., Khosla C., St Onge R. P., Tang Y., Hillenmeyer M. H.* “HEx: a heterologous expression platform for the discovery of fungal natural products.” Sci. Adv. 2018, 4: eaar5459.

  • Li L.#, Tang M.-C.#, Tang S., Gao S., Soliman S., Hang L., Xu W., Ye T., Watanabe K., Tang Y.* “Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids.” J. Am. Chem. Soc. 2018, 140, 2067-2071.

  • Tang M.-C. #, Cui X. #, He X., Ding Z., Zhu T., Tang Y.*, Li D.* “Late-Stage Terpene Cyclization by an Integral Membrane Cyclase in the Biosynthesis of Isoprenoid Epoxycyclohexenone Natural Products.” Org. Lett. 2017, 19, 5736-5739.

  • Hang L.#,Tang M.-C.#, Harvey C. J. B., Page C. G., Li J., Hung Y.-S., Liu N., Hillenmeyer M. E., Tang Y.* “Reversible Product Release and Recapture by a Fungal Polyketide Synthase Using a Carnitine Acyltransferase Domain.” Angew. Chem. Int. Ed. 2017, 56, 9556-9560.

  • Tang M.-C.#, Zou Y.#, Watanabe K., Walsh C. T.*, Tang Y.* “Oxidative Cyclization in Natural Product Biosynthesis.” Chem. Rev. 2017, 117, 5226-5333. (Invited review)

  • Tang M.-C., Lin H.-C., Li D., Zou Y., Li J., Xu W., Cacho R. A., Hillenmeyer M. E., Garg N. K., Tang Y.* “Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast.” J. Am. Chem. Soc. 2015, 137, 13724-13727.