• 2002.09-2007.07：中国科学院上海有机化学研究所，博士

• 1998.09-2002.07：华东师范大学化学系，本科

• 2022.10-至今：上海交通大学张江高等研究员，教授（兼）

• 2020.09-至今：上海交通大学生命科学技术学院，教授

• 2012.01-2020.08：武汉大学药学院，教授

• 2011.01-2011.12：中国科学院上海有机化学研究所，副研究员

• 2008.11-2010.12：中国科学院上海有机化学研究所，助理研究员

• 2007.09-2008.10：美国麻省理工学院化学系，博士后

• 天然产物碳骨架的生物合成与编辑：研究聚酮、含氮杂环和甾体三大类药用分子碳骨架的形成机制，发展高效的生物合成方法用于碳骨架合成和结构修饰，开发创新药物和实现药物的高效生产。

荣誉奖励：

• 2024 国家级高层次人才

• 2023 国家技术标准创新基地（乳业）金鬲创新项目奖（第3）

• 2023 第九届中国国际互联网+大学生创新创业大赛上海赛区铜奖（指导教师）

• 2023 中央高校优秀青年团队带头人

• 2022 上海市优秀学术带头人

• 2013 国家优秀青年科学基金

• 2012 国家级优秀青年人才

• 2012 武汉大学珞珈学者

承担项目

• 2025-2029：国家杰出青年科学基金

• 2023-2025：企业开发项目/甾体生物转化技术

• 2023-2025：中央高校优秀青年团队培育项目

• 2023-2026：上海市自然科学基金/面上项目

• 2023-2026：国家自然科学基金/面上项目

• 2022-2025：上海市优秀学术带头人

• 2020-2023：国家自然科学基金/面上项目

• 2020-2023：企业开发项目/甾体生物转化技术

• 2020：上海交通大学科研启动经费

• 2018-2020：武汉大学创新培育项目

• 2019-2024：国家重点研发计划/高版本工业放线菌底盘/任务

• 2018-2021：国家重点研发计划/中药资源合成生物学研究/课题

• 2018-2021：国家自然科学基金/面上项目

• 2017-2019：微生物代谢国家重点实验室开放课题

• 2016-2019：国家自然科学基金/面上项目

• 2014-2016：国家优秀青年科学基金

• 2013-2016：国家自然科学基金/面上项目

• 2013-2015：材料化学工程国家重点实验室开放课题

• 2013-2015：教育部新世纪优秀人才支持计划

• 2013-2015：生命有机化学国家重点实验室开放基金

• 2012：武汉大学科研启动经费

• 2010-2012：国家自然科学基金/青年项目

• 2010-2011：教育部留学回国人员科研启动基金（第39批）

• Xiaoli Yan, Xinying Jia, Zhenyao Luo, Shunjia Ji, Meng-Jie Zhang, Hui Zhang, Mingjia Yu, Julie Orts, Kai Jiang, Zhi Lin, Zixin Deng, Xu-Dong Kong, Bostjan Kobe, Yi-Lei Zhao, Mehdi Mobli, Xudong Qu. An enzymatic dual-oxa Diels-Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (-)-anthrabenzoxocinones. Nature Chemistry 2024 accepted.

• Guangzheng Wei, Borui Duan, Tai-Ping Zhou, Wenya Tian, Chenghai Sun, Zhi Lin, Zixin Deng, Binju Wang, Zhengyu Zhang, Xudong Qu. A Nucleobase-driven P450 peroxidase system enables regio- and stereo-specific formation of C‒C and C‒N bonds. Proceedings of the National Academy of Sciences of the United States of America 2024, 121, e2412890121.

• Kai Jiang, Xu Chen, Xiaoli Yan, Zixin Deng, Shunkun Luo, Xudong Qu. An unusual aromatase/cyclase programs the formation of the phenyldimethylanthrone framework in anthrabenzoxocinones and fasamycin. Proceedings of the National Academy of Sciences of the United States of America 2024, 121, e2321722121.

• Chenghai Sun, Bao-Di Ma, Guangjun Li, Wenya Tian, Lu Yang, Haidong Peng, Zhi Lin, Zixin Deng, Xu-Dong Kong, Xudong Qu. Engineering the substrate specificity of a P450 dimerase enables the collective biosynthesis of heterodimeric tryptophan-containing diketopiperazines. Angewandte Chemie International Edition 2023, 62, e202304994.

• Zhi Lin, Zhiwei Hu, Linjun Zhou, Benben Liu, Zixin Deng, Xudong Qu. A large conserved family of small molecule carboxyl methyltransferases identified from Microorganisms. Proceedings of the National Academy of Sciences of the United States of America 2023, 120, e2301389120.

• Fuzhen Song, Mengmeng Zheng, Junlin Wang, Huanhuan Liu, Zhi Lin, Benben Liu, Zixin Deng, Hengjiang Cong, Qianghui Zhou, Xudong Qu. Chemoenzymatic synthesis of C14-functionalized steroids. Nature Synthesis 2023, 2, 729-739.

• Chenghai Sun, Wenya Tian, Zhi Lin, Xudong Qu. Biosynthesis of pyrroloindoline-containing natural products. Natural Products Reports 2022, 39, 1721-1765.

• Jinmei Zhu, Lu Yang, Jiequn Wu, Zixin Deng, Xudong Qu. Engineering imine reductase for efficient biosynthesis of 1-aryl-tetrahydro-β-carbolines and their N-methylation products. ACS Catalysis 2022, 12, 9823-9830.

• Mengmeng Zheng, Jun Zhang, Wan Zhang, Lu Yang, Xiaoli Yan, Wenya Tian, Zhihao Liu, Zhi Lin, Zixin Deng, Xudong Qu. An atypical acyl-CoA synthetase enables efficient biosynthesis of extender units for engineering a polyketide carbon scaffold. Angewandte Chemie International Edition 2022, 61, e202208734.

• Xiaoli Yan, Jun Zhang, Hongqun Tan, Zhihao Liu, Kai Jiang, Wenya Tian, Mengmeng Zheng, Zhi Lin, Zixin Deng, Xudong Qu. A Pair of atypical KAS III homologues with initiation and elongation functions programs the polyketide biosynthesis in asukamycin. Angewandte Chemie International Edition 2022, 61, e202200879.

• Haidong Peng, Yaya Wang, Kai Jiang, Xinru Chen, Wenlu Zhang, Yanan Zhang, Zixin Deng, Xudong Qu. A dual role reductase from phytosterol catabolism enables efficient production of valuable steroid precursors. Angewandte Chemie International Edition 2021, 60, 5414-5420.

• Jun Zhang, Mengmeng Zheng, Zixin Deng, Dongqing Zhu, Xudong Qu. A permissive medium chain acyl-CoA carboxylase enables the efficient biosynthesis of extender units for engineering polyketide carbon scaffolds. ACS Catalysis 2021, 11, 12179-12185.

• Chenghai Sun, Zhenyao Luo, Wenlu Zhang, Wenya Tian, Haidong Peng, Zhi Lin, Xiaoli Yan, Yanan Zhang, Zixin Deng, Bostjan Kobe, Xinying Jia, Xudong Qu. Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric ketopiperazines. Nature Communications 2020, 11, 6251.

• Lu Yang, Jinmei Zhu, Chenghai Sun, Zixin Deng, Xudong Qu. Biosynthesis of plant tetrahydroisoquinolines alkaloids through an imine reductase route. Chemical Science 2020, 11, 364-371 (2019 Chemical Science HOT Article Collection).

• Junlin Wang, Yanan Zhang, Linjun Zhou, Linpeng Wei, Wenbing Yin, Zixin Deng, Xudong Qu, Qianghui Zhou. A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids. Nature Communications 2019, 10, 3378.

• Wenya Tian, Chenghai Sun, Mei Zheng, Mingjia Yu, Yanan Zhang, Haidong Peng, Dongqing Zhu, Jeffery Harmer, Zixin Deng, Shilu Chen, Mohedi Mobli, Xinying Jia, Xudong Qu. Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids. Nature Communications 2018, 9, 4428.

• Yuan Li, Wan Zhang, Hui Zhang, Wenya Tian, Lian Wu, Shuwen Wang, Jun Zhang, Chenghai Sun, Yuhui Sun, Zixin Deng, Xudong Qu, Jiahai Zhou. Structural basis of a broadly selective acyltransferase from the polyketide synthase of splenocin. Angewandte Chemie International Edition 2018, 57, 5823-5827.

• Jinmei Zhu, Hongqun Tan, Lu Yang, Zheng Dai, Lu Zhu, Hongmin Ma, Zixin Deng, Zhenghua Tian, Xudong Qu. Enantioselective synthesis of 1-aryl-substituted tetrahydroisoquinolines employing imine reductase. ACS Catalysis 2017, 7, 7003-7007.

• Chengcheng Chang, Rong Huang, Yan Yan, Hongmin Ma, Zheng Dai, Benying Zhang, Wen Liu, Zixin Deng, Xudong Qu. Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into Polyketide carbon scaffolds. Journal of the American Chemical Society 2015, 137, 4183-4190.

• Qiongqiong Wu, Zhuhua Wu, Xudong Qu, Wen Liu. Insights into pyrroindomycin biosynthesis reveal a uniform paradigm for tetramate/tetronate formation. Journal of the American Chemical Society 2012, 134, 17342-17345.

• Xudong Qu*, Bo Pang, Zicong Zhang, Ming Chen, Zhuhua Wu, Qunfei Zhao, Qinglin Zhang, Yingyan Wang, Yun Liu, Wen Liu*. Caerulomycins and collismycins share a common paradigm for 2, 2’-bipyridine biosynthesis via an unusual hybrid polyketide-peptide assembly logic. Journal of the American Chemical Society 2012, 134, 9038-9041.