
副研究员
电子邮箱:hao.yang1@sjtu.com.cn
个人网页/课题组主页:
教育背景
工作经历
研究方向
荣誉奖励/承担项目
代表性论文和著作
2006-2010 西南大学 学士
2010-2015 迈阿密大学 博士
2015-2023 西北大学化学院 博士后
2023-2026 西北大学化学院 研究助理教授
2026-至今 上海交通大学张江高等研究院 副研究员
自由基SAM酶,固氮酶,电子顺磁共振
H. Yang, M. B. Ho, M. N. Lundahl, M. A. Mosquera, W. E. Broderick, J. B. Broderick, B. M. Hoffman. ENDOR Spectroscopy Reveals the ‘Free’ 5′-deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S]2+ Cluster. J. Am. Chem. Soc. 146, 6, 3710-3720, 2024
H. Yang, E. C. McDaniel, S. Impano, A. S. Byer, R, J. Jodts, K.Yokoyama, W. E. Broderick, J. B. Broderick, B. M. Hoffman. The Elusive 5′-Deoxyadenosyl Radical: Captured and Characterized by EPR and ENDOR Spectroscopies. J. Am. Chem. Soc. 141, 12139-12146, 2019
H. Yang, S. Impano, E. M. Shepard, C. D. James, W. E. Broderick, J. B. Broderick, B. M. Hoffman. Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an S-AdenosylMethionine Derived Methyl Radical. J. Am. Chem. Soc. 141, 16117-16124, 2019
H. Yang, M. Aitha, A. R. Marts, A. M. Hetrick, B. Bennett, M. W. Crowder, and D. L. Tierney. Spectroscopic and Mechanistic Studies of Heterodimetallic Forms of Metallo--Lactamase NDM-1. J. Am. Chem. Soc. 136, 7273-7285, 2014
S. Impano†, H. Yang†, R. Jodts†, A. Pagnier, R. Swimley, E. McDaniel, E. Shepard, W. E. Broderick, J. B. Broderick, B. M. Hoffman. Active-Site Controlled, Jahn-Teller Enabled Regioselectivity in Reductive S-C Bond Cleavage of S-Adenosylmethionine (SAM) in Radical-SAM Enzymes. J. Am. Chem. Soc. 143, 335-348, 2021 (†并列一作)
Pagnier†, H. Yang†, R. Jodts, C. D. James, E. M. Shepard, S. Impano, W. E. Broderick, J. B. Broderick, B. M. Hoffman. Radical SAM Enzyme Spore Photoproduct Lyase: Properties of the Ω Organometallic Intermediate and Identification of Stable Protein Radicals Formed during Substrate-Free turnover. J. Am. Chem. Soc. 142, 18650-18660, 2020 (†并列一作)
H. Yang, A. Sharma, M. J. Daly*, and B. M. Hoffman.* The Ternary Complex of Mn2+, Synthetic Decapeptide DP1 (DEHGTAVMLK), and Orthophosphate is a Superb Superoxide Dismutase. Proc. Natl. Acad. Sci. USA, doi.org/10.1073/pnas.2417389121, 2024
Hao Yang, Alex S. Drena, George E Cutail III, J. C. Peters, and B. M. Hoffman, EPR and 31P ENDOR Characterization of Pseudo-Jahn-Teller Dynamics and N2 Activation in Functional Nitrogenase Models, P3EM(N2) (M = Fe, Co; E = Si, B, C), Inorg. Chem. 64, 18346-18355, 2025
H. Yang, J. Rittle, A. R. Marts, J. C. Peters, and B. M. Hoffman. ENDOR Characterization of (N2)FeII(-H)2FeI(N2)-: a Spectroscopic Model for N2 Binding by the di--hydrido Nitrogenase Janus Intermediate. Inorg. Chem. 57, 12323-12330, 2018.
J. L. Martinez, S. A. Lutz., H. Yang, J.X. Xie., J. Telser, B. M. Hoffman., V. Carta, M. Pink, Y. Losovyj, J. M. Smith. Structural and Spectroscopic Characterization of an Fe(VI) bis(imido) Complex. Science. 370. 356-359, 2020