合成化学平台

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王大力

  • 课题组长

  • 长聘教轨副教授

  • 电子邮箱:energywang@sjtu.edu.cn

  • 教育背景

  • 工作经历

  • 研究方向

  • 荣誉奖励/承担项目

  • 代表性论文专著

  • 2009.09-2016.02   上海交通大学   博士

  • 2005.09-2009.07   东华大学       学士

  • 2022.11-至今     上海交通大学   长聘教轨副教授

  • 2019.10-2022.10  哈佛大学医学院 博士后

  • 2016.03-2019.09  美国东北大学   博士后

  • 生物医用高分子材料;药物递送;核酸药物;基因治疗

  • 2021年 国家优秀青年科学基金(海外)

  • 2019年 美国Gordon Research Conference 最佳海报奖

  • 2016年 上海市优秀博士毕业生

  • Wang, D.; Li, Y.; Deng, X.; Torre, M.; Zhang, Z.; Li, X.; Zhang, W.; Cullion, K.; Kohane, D. S.*; Weldon, C. B.*, An aptamer-based depot system for sustained release of small molecule therapeutics. Nat. Commun. 2023, 14, 2444.

  • Wang, D.; Wang, Q.; Wang, Y.; Chen, P.; Lu X.; Jia, F.; Sun, Y.; Sun, T.; Zhang, L.; Che, F.; He, J.; Lian, L.; Morano, G.; Shen, M.; Ren, M.; Dong, S.; Zhao, J.*; Zhang, K.*, Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides. Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2113180119.

  • Xu, L.; Yu, C.; Wang, D.*; Pang, J.; Shi, L.; Su, Y.; Gong, L.; Yan, D.; Zhu, X.*, Endogenous nucleotide as drug carrier: base-paired guanosine-5’-monophosphate: pemetrexed vesicles with enhanced anticancer capability. Sci. China Chem. 2020, 63, 244-253.

  • Wang, D.; Jia, F.; Tan, X.; Wang, Y.; Sun, X.; Cao, X.; Che, F.; Lu, H.; Gao, X.; Shimkonis, J.; Nyoni, Z.; Lu, X.*; Zhang, K.*, Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo. Sci. Adv. 2019, 5, eaav9322.

  • Wang, D.; Yu, C.; Xu, L.; Shi, L.; Tong, G.; Wu, J.; Liu, H.; Yan, D.; Zhu, X.*, Nucleoside analogue based supramolecular nanodrugs driven by molecular recognition for synergistic cancer therapy. J. Am. Chem. Soc. 2018, 140, 8797-8806.

  • Wang, D.; Liu, B.; Ma, Y.; Wu, C.; Mou, Q.; Deng, H.; Wang, R.; Yan, D.; Zhang, C.*; Zhu, X.*, A molecular recognition approach to synthesize nucleoside analogue based multifunctional nanoparticles for targeted cancer therapy. J. Am. Chem. Soc. 2017, 139, 14021-14024.

  • Wang, D.; Lu, X.; Jia, F.; Tan, X.; Sun, X.; Cao, X.; Wai, F.; Zhang, C.*; Zhang, K.*, Precision tuning of DNA-and poly (ethylene glycol)-based nanoparticles via coassembly for effective antisense gene regulation. Chem. Mater. 2017, 29, 9882-9886.

  • Wang, D.; Jin, Y.; Zhu, X.*; Yan, D.*, Synthesis and applications of stimuli-responsive hyperbranched polymers. Prog. Polym. Sci. 2017, 64, 114-153.

  • Wang, D.; Tu, C.; Su, Y.; Zhang, C.; Greiser, U.; Zhu, X.*; Yan, D.; Wang, W.*, Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery. Chem. Sci. 2015, 6, 3775-3787.

  • Wang, D.; Zhao, T.; Zhu, X.*; Yan, D.; Wang, W.*, Bioapplications of hyperbranched polymers. Chem. Soc. Rev. 2015, 44, 4023-4071.