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Shu QUAN

  • Professor

  • Email address: shuquan@sjtu.edu.cn

  • EDUCATION

  • WORKING EXPERIENCE

  • RESEARCH

  • HONORS AND AWARDS

  • PUBLICATIONS

  • 2004-2010    University of Michigan  Doctor of Philosophy

  • 2000-2004    Tsinghua University   Bachelor of Science

  • 2024-now    Shanghai Jiao Tong University, School of Life Sciences and Biotechnology, Professor

  • 2014-2024     East China University of Science and Technology, School of Biotechnology, Professor

  • 2010-2013    Howard Hughes Medical Institute/ University of Michigan     Research Associate

  • Protein folding biosensors, Chaperone biology and engineering, Enzyme engineering, Mechanisms and proteostasis of epigenetic enzymes

  • National Excellent Young Scientist

  • High-level Talent of Shanghai

  • He W.*, Yang Y., Qian Y., Chen Z., Zheng Y., Zhao W., Yan C., Guo Z., and Quan, S.* Fluorogenic sensing of amorphous aggregates, amyloid fibers, and chaperone activity via a near-infrared aggregation-induced emission-active probe. Aggregate (2024) 5(1): e412.

  • He, W.#, Li, X. #, Xue, H., Yang, Y., Mencius, J., Bai, L., Zhang, J., Xu, J., Wu, B.*, Xue, Y.*, and Quan, S.* Insights into the client protein release mechanism of the ATP-independent chaperone Spy. Nature Communications (2022) 13(1): 2818.

  • Li. Y.#, Zhao. L.#, Zhang. Y. #, Wu. P.#, Xu. Y., Mencius. J., Zheng. Y., Wang. X., Xu. W., Huang. N., Ye. X., Lei. M., Shi. P., Tian. C., Peng. C.*, Li. G.*, Liu. Z.*, Quan. S.*, Chen. Y.* Structural basis for product specificities of MLL family methyltransferases. Molecular Cell (2022) 82(20):3810-3825.e8.

  • Ren, C., Wen, X., Mencius, J., and Quan, S.* An enzyme-based biosensor for monitoring and engineering protein stability in vivo. Proc Natl Acad Sci U S A (2021) 118(13): e2101618118.

  • He, W. #, Yu, G. #, Li, T., Bai, L., Yang, Y., Xue, Z., Pang, Y., Reichmann, D., Hiller, S., He, L.*, Liu, M.*, and Quan, S.* Chaperone Spy Protects Outer Membrane Proteins from Folding Stress via Dynamic Complex Formation. mBio (2021) 12(5): e0213021.