搜索
Xudong QU
Professor
Email address: quxd19@sjtu.edu.cn
EDUCATION
WORKING EXPERIENCE
RESEARCH
HONORS AND AWARDS
PUBLICATIONS
2002-2007 Shanghai institute of Organic Chemistry, Chinese Academy of Sciences, Doctor of Philosophy.
1998-2002 East China Normal University, Department of Chemistry, Bachelor of Science.
2020-Present Shanghai Jiao Tong University, School of Life Sciences and Biotechnology/ Zhangjiang Institute of Advanced study, Professor
2012-2020 Wuhan University, School of Pharmaceutical Sciences, Professor
2011-2012 Shanghai institute of Organic Chemistry, Chinese Academy of Sciences, Associate Investigator
2008-2010 Shanghai institute of Organic Chemistry, Chinese Academy of Sciences, Assistant Investigator
Explore the biosynthesis of natural products and develop biosynthetic methods for the production of important molecules for drug discovery and large-scale biomanufacturing.
National Science Fund for Distinguished Young Scholars (2024).
Gold Ge Innovation Project Award, National Technical Standard Innovation Base (Dairy) (2023).
Leader of Outstanding Young Team, Central Universities (2023).
Shanghai Outstanding Academic Leader (2022).
National Science Fund for Excellent Young Scholars (2013).
New Century Excellent Talent, Ministry of Education (2012).
Xiaoli Yan, Xinying Jia, Zhenyao Luo, Shunjia Ji, Meng-Jie Zhang, Hui Zhang, Mingjia Yu, Julie Orts, Kai Jiang, Zhi Lin, Zixin Deng, Xu-Dong Kong, Bostjan Kobe, Yi-Lei Zhao, Mehdi Mobli, Xudong Qu. An enzymatic dual-oxa Diels-Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (-)-anthrabenzoxocinones. Nat. Chem. 2025, DOI: 10.1038/s41557-025-01804-0.
Kai Jiang, Cheng Zhu, Xiaoli Yan, Guangjun Li, Zhi Lin, Ming Jiang, Zixin Deng, Shukun Luo, Xudong Qu. A stereoselective decarboxylative aromatase/cyclase directs the biosynthesis of an axially chiral biphenyl framework in fasamycin. J. Am. Chem. Soc. 2025, 147, 5596-5601.
Guangzheng Wei, Borui Duan, Tai-Ping Zhou, Wenya Tian, Chenghai Sun, Zhi Lin, Zixin Deng, Binju Wang, Zhengyu Zhang, Xudong Qu. A Nucleobase-driven P450 peroxidase system enables regio- and stereo-specific formation of C‒C and C‒N bonds. Proc. Natl. Acad. Sci. USA 2024, 121, e2412890121.
Kai Jiang, Xu Chen, Xiaoli Yan, Zixin Deng, Shunkun Luo, Xudong Qu. An unusual aromatase/cyclase programs the formation of the phenyldimethylanthrone framework in anthrabenzoxocinones and fasamycin. Proc. Natl. Acad. Sci. USA 2024, 121, e2321722121.
Fuzheng Song, Mengmeng Zheng, Junlin Wang, Huanhuan Liu, Zhi Lin, Bengbeng Liu, Zixin Deng, Qianghui Zhou, Xudong Qu. A chemoenzymatic approach to C14-functionalized steroids. Nat. Synth. 2023, 2, 729-739.
Zhi Lin, Zhiwei Hu, Linjun Zhou, Benben Liu, Xiaowei Huang, Zixin Deng, Xudong Qu. A large conserved family of small-molecule carboxyl methyltransferases identified from microorganisms. Proc. Natl. Acad. Sci. USA 2023, 120, e2301389120.
Chenghai Sun, Bao-Di Ma, Guangjun Li, Wenya Tian, Lu Yang, Haidong Peng, Zhi Lin, Zixin Deng, Xu-Dong Kong, Xudong Qu. Engineering the substrate specificity of a P450 dimerase enables the collective biosynthesis of heterodimeric tryptophan-containing diketopiperazines. Angew. Chem. Int. Ed. 2023, 62, e202304994.
Xiaoli Yan, Jun Zhang, Hongqun Tan, Zhihao Liu, Kai Jiang, Wenya Tian, Mengmeng Zheng, Zhi Lin, Zixin Deng, Xudong Qu. A pair of atypical KAS III homologues with initiation and elongation functions programs the polyketide biosynthesis in asukamycin. Angew. Chem. Int. Ed. 2022, e202200879.
Mengmeng Zheng, Jun Zhang, Wan Zhang, Lu Yang, Xiaoli Yan, Wenya Tian, Zhihao Liu, Zhi Lin, Zixin Deng, Xudong Qu. An atypical acyl-CoA synthetase enables efficient biosynthesis of extender units for engineering a polyketide carbon scaffold. Angew. Chem. Int. Ed. 2022, e202208734.
Haidong Peng, Yaya Wang, Yanan Zhang, Zixing Deng, Zhenghua Tian, Xudong Qu. A dual role reductase from phytosterol catabolism enables efficient production of valuable steroid precursors. Angew. Chem. Int. Ed. 2021, 60, 5414-5420.
沪交ICP备201251287 Copyright © 2025 ZIAS
Address：No.1308 Keyuan Road, Pudong District, Shanghai
Phone：86-21-54740000
E-mail：zias@sjtu.edu.cn
