Yike ZOU

  • Professor

  • Email address: zouyike@sjtu.edu.cn

  • EDUCATION

  • WORKING EXPERIENCE

  • RESEARCH

  • HONORS AND AWARDS

  • PUBLICATIONS

  • 2003–2010 B.Sc. and M.Sc., Chengdu University of Traditional Chinese Medicine

  • 2012–2017 Ph.D., University of Pennsylvania, USA

  • 2018–2022 Postdoctoral Researcher, University of California, Los Angeles (UCLA)

  • 2021–2022 Lecturer, University of California, Los Angeles (UCLA)

  • 2022–2023 Research Scientist, Lawrence Livermore National Laboratory

  • 2024–Present Tenure-track Associate Professor, School of Pharmacy, Shanghai Jiao Tong University

  • AI-driven drug design

  • Enzyme design

  • Medicinal chemistry

  • Computational chemistry

  • 2016 Chinese Government Award for Outstanding Self-financed Students Abroad

  • 2021 National-level Young Overseas Talent Program

  • Gao, J.; Liu, S.; Zhou, C.; Lara, D.; Zou, Y.*; Hai, Y.* “A pyridoxal 5′-phosphate-dependent Mannich cyclase.” Nature Catalysis 2023, 1-11.

  • Zou, Y.*; Houk, K. N.*, “Mechanisms and Dynamics of Synthetic and Biosynthetic Formation of Delitschiapyrones: Solvent Control of Ambimodal Periselectivity” J. Am. Chem. Soc. 2021, 143 (30), 11734-11740.

  • Zou, Y.; Yang, S.; Sanders, J. N.; Li, W.; Yu, P.; Wang, H.; Tang, Z.; Liu, W.; Houk, K.N. “Computational Investigation of the Mechanism of Diels–Alderase PyrI4.” J. Am. Chem. Soc. 2020, 142, 20232-20239.

  • Zou, Y.; Wong, J.; Houk, K. N. “Computational exploration of a redox-neutral organocatalytic Mitsunobu reaction” J. Am. Chem. Soc. 2020, 142, 38, 16403–16408.

  • Zou, Y.‡; Wang, X. ‡; Sims, J.; Wang, B.; Pandey, P.; Welsh, C. L.; Stone, R. S.; Avery, M. A.; Doerksen, R. J.; Ferreira, D.; Anklin, C.; Valeriote, F. A.; Kelly, M.; Hamann, M. T. “Computationally-assisted discovery and assignment of a highly strained and PANC-1 selective alkaloid from Alaska’s deep ocean” J. Am. Chem. Soc. 2019, 141, 4338-4344.

  • Zou, Y.; Li, X.; Yang, Y.; Berritt, S.; Melvin, J.; Gonzales, S.; Spafford, M.; Smith, A. B. “Total synthesis of (−)-nodulisporic acids D, C, and B: evolution of a unified synthetic strategy” J. Am. Chem. Soc. 2018, 140, 9502.